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    Drugs with a Narrow Therapeutic Index Digoxin: A single dose of eszopiclone 3 mg did not affect the pharmacokinetics of digoxin measured at steady state lunesta following dosing of 0 . 5 mg twice daily lunesta for one day and 0 . 25 mg lunesta and ativan side effects of lunesta 3 eszopiclone and venlafaxine lunesta generic dose daily for the next 6 days .
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    Drugs Highly Bound to Plasma Protein Eszopiclone is not highly bound to plasma proteins (52-59% bound); therefore, the disposition of eszopiclone is not expected to be sensitive lunesta to alterations in protein binding .
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    NONCLINICAL TOXICOLOGY Carcinogenesis, Mutagenesis, Impairment of Fertility In a carcinogenicity study in rats, oral administration of eszopiclone for 97 (males) or 104 (females) weeks resulted in no increases in tumors; plasma levels (AUC) of eszopiclone at the highest dose tested (16 mg/kg/day) are approximately 80 (females) and 20 lunesta (males) times those in humans at the maximum recommended human dose (MRHD) of 3 mg/day .

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