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The tablets should be swallowed clonidine whole with water .
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Use in clonidine Impaired Renal Function Doses must be adjusted according to the degree of impairment and patients should be carefully monitored .
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clonidine Use in Impaired Hepatic Function Dosage instructions for patients with impaired hepatic function have not been established .
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The signs and symptoms of clonidine hydrochloride overdosage include generalised sympathetic depression and include pupillary constriction, hypotension, hypothermia, clonidine bradycardia, lethargy, irritability, weakness, somnolence including coma, diminished or absent reflexes, vomiting and hypoventilation .
clonidine 5 and 6 . With large overdoses, reversible cardiac induction defects or arrhythmias, coma, respiratory depression including apnoea, seizures and transient hypertension have been In a patient clonidine who ingested 100 mg clonidine hydrochloride, plasma clonidine levels were 60 ng/mL (one hour), 190 ng/mL (1 . 5 clonidine hours), 370 ng/mL (two hours) and 120 ng/mL (5 . 5 clonidine hours) .
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