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    Since Valium has a central nervous system depressant effect, patients should be advised against the diazepam simultaneous ingestion of alcohol and other CNSdepressant drugs during Valium therapy .
    As with other agents that have anticonvulsant activity, when Valium is used as an adjunct in treating convulsive disorders, the possibility of an increase in the diazepam frequency and/or severity of grand mal seizures may require an increase in the dosage of standard anticonvulsant medication .
    Abrupt withdrawal of Valium in such cases may also be associated with a temporary increase in the frequency and/or diazepam severity of seizures .

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