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Approximately 4% of 1,959 patients who received zolpidem zolpidem at all doses (1 to 50 mg) in similar foreign trials discontinued treatment because of an adverse reaction .
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Data from a clinical study in which selective serotonin reuptake inhibitor (SSRI)-treated patients were given zolpidem revealed that four of the seven discontinuations during double-blind treatment with zolpidem (n=95) were associated with impaired concentration, continuing or aggravated depression, and manic reaction; one patient treated zolpidem with placebo (n =97) was discontinued after an attempted suicide .
Most commonly observed adverse reactions in controlled trials: During short-term treatment (up to 10 nights) with Ambien at doses up to 10 mg, the most commonly observed adverse reactions associated with the use of zolpidem and seen at zolpidem statistically significant differences from placebo-treated patients were drowsiness (reported by 2% of zolpidem patients), dizziness (1%), and diarrhea (1%) .
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