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Decreased seizure diazepam activity .
Pharmacokinetics Absorption: Rapidly absorbed diazepam from the GI tract .
Absorption from IM diazepam sites may be slow and unpredictable .
Well absorbed (90%) from diazepam is an example of a valium na modach valium green diazepam y lactancia valium dosage weight rectal mucosa .
diazepam 5 mg spc valium dose drugs forum valium gynecomastia diazepam 10 mg rectal kit valium vs Distribution: Widely distributed .
Crosses the blood-brain diazepam 5mg reviews valium dosage iv diazepam tablets 5mg diazepam 10 mg efectos diazepam online barrier .
Crosses the placenta; enters breast diazepam milk .
Metabolism and Excretion: Highly metabolized by the hepatic P450 enzymes (CYP2C19 valium effects diabetes valium vs zopiclone valium dentist valium pills look like longer half life and CYP3A4); the CYP2C19 enzyme system exhibits genetic polymorphism; 15– 20% of Asian patients and 3– 5% of Caucasian and Black patients may be poor metabolizers and may have significantlyqdiazepam concentrations and an ⫽ Canadian drug name .
Contraindications/Precautions Contraindicated in: Hypersensitivity; Cross-sensitivity with diazepam other benzodiazepines may occur; Comatose patients; Myasthenia gravis; Severe pulmonary impairment; Sleep apnea; Severe hepatic dysfunction; Pre-existing CNS depression; Uncontrolled severe pain; Angle-closure glaucoma; Some products contain alcohol, propylene glycol, or tartrazine and should be avoided in patients with known hypersensitivity or intolerance; OB:qrisk of congenital malformations; Pedi: Children ⬍6 mo (for oral; safety not established); Lactation: Recommend to discontinue drug Use Cautiously in: Severe renal impairment; History of suicide attempt or drug dependence; Debilitated patients (dose p required); Patients with low albumin; Pedi: Metabolites can accumulate in neonates .
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