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    The changes in migraine frequency represent a median percent reduction of 35%, 49%, and 48% in the TOPAMAX® 50, 100, and 200 mg/day groups, respectively, versus 19% in the topamax placebo group .
    In both studies, there were no apparent differences in treatment effect within age, gender or topamax racial In the migraine prophylaxis clinical trials in approximately 900 patients, daily dosages were decreased when required in weekly intervals by 25 to 50 mg in adults receiving TOPAMAX® at doses up to 100 mg/day .
    1: Reduction in 4-Week Migraine Headache Frequency (Studies TOPMAT-MIGR-001 and TOPMAT-MIGR-002) Change From Baseline to Double-Blind Phase in Average Monthly Migraine Period Rate (+SE) (N=115 and 114) (N= 117 and 117) (N=125 and 120) (N=112 and 117) * p topamax capsules topamax for mental health can topamax cause migraines long term effects of topamax <0 . 0 cumulative response rate, change in average monthly migraine attack rate, change in the average monthly rate of rescue medication use, change in the average number of monthly migraine days and onset of action topamax defined as the earliest month that there was a statistically significant difference between each topiramate treatment group and placebo with respect to the primary efficacy endpoint that was maintained for the remainder of the double-blind phase . doc topamax EDMS-ERI-96423815 v14 . 001 Additional efficacy measures that were assessed, in both studies, topamax birth defects what’s topamax used for topamax class how many mg of topamax for weight loss included responder rate, TOP 03222019CPM_NC 222972 . 010, ** p topamax <0 . topamax Figure 2 .
    Comparative Bioavailability Studies The sprinkle formulation topamax is bioequivalent to the immediate-release tablet formulation and therefore may be substituted as a therapeutic equivalent .

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